Piperacillin/tazobactam (ZOSYN)

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Piperacillin/Tazobactam (ZOSYN)

}iperacillin/tazobactam (ZOSYN, Lederle Laboratories, Pearl River, NY) is the most recently approved combination of a [3-1actam antimicrobial agent with an inhibitor of bacterial [3-1actamases. In vitro and clinical studies have demonstrated efficacy in polymicrobial infections such as obstetric, gynecologic, and soft-tissue infections. Piperacillin/ tazobactam appears to be an appropriate drug...

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Zosyn® (piperacillin/tazobactam) reformulation: Expanded compatibility and coadministration with lactated Ringer’s solutions and selected aminoglycosides

Zosyn((R)) , also known as Tazocin((R)) for injection, contains piperacillin and tazobactam and was approved by the US Food and Drug Administration in 1993 for the treatment of indicated serious infections. In 1995, United States Pharmacopoeia and European Pharmacopoeias reduced the particulate limit for injectables by 40%, based on general safety concerns. Wyeth attempted to control sporadic b...

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The Ecology of Antibiotic Use in the ICU: Homogeneous Prescribing of Cefepime but Not Tazocin Selects for Antibiotic Resistant Infection

BACKGROUND Antibiotic homogeneity is thought to drive resistance but in vivo data are lacking. In this study, we determined the impact of antibiotic homogeneity per se, and of cefepime versus antipseudomonal penicillin/β-lactamase inhibitor combinations (APP-β), on the likelihood of infection or colonisation with antibiotic resistant bacteria and/or two commonly resistant nosocomial pathogens (...

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1244-1248 Ahmed LAJP 3341:Ahmed

The refractory nature of Pseudomonas infections to chemotherapy reflects its ability to rapidly acquire resistance and adapt to hostile environment. In order to keep eye on changing trends in susceptibility patterns of Pseudomonas sp. and to modify therapeutic choices, a retrospective study was carried out. Samples for culture and sensitivity testing were screened for presence of Pseudomonas sp...

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Comparative study of resistance to antibiotics of strains of Klebsiella isolated in urinary and respiratory infections

Results The resistance to antibiotics was higher in Klebsiella pneumoniae strains isolated from urine culture compared to those isolated in respiratory infections in case of: a) beta-lactams (ceftriaxone 45.2% versus 69.5%, cefaclor 36.7% versus 52.9%, cefuroxime 49.3% versus 61.9%, cefoperazone-sulbactam 70.6% versus 85.7%, piperacillintazobactam 58.1% versus 75.5%, aztreonam 45.8% versus 66.6...

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ژورنال

عنوان ژورنال: Infectious Diseases in Obstetrics and Gynecology

سال: 1996

ISSN: 1064-7449,1098-0997

DOI: 10.1002/(sici)1098-0997(1996)4:5<258::aid-idog3>3.0.co;2-u